Hepatology . 1 This protein-enriched interface exhibits a thickness in the 0.5–1 μm range and plays a critical role in the transfer of signaling molecules and nutrients between hepatic cells. The distribution of two major basement membrane components, type IV collagen and laminin, was studied within the perisinusoidal space of Disse in normal human liver using (i) an immunoperoxidase method for light microscopy and (ii) immunogold labelling for ultrastructural localisation. 12,13 In the liver, hepatic parenchymal cells are separated from NPCs by an interfacial region known as the Space of Disse. ディッセ腔には 血漿 が含まれる。. Microvilli of hepatocytes extend into this space, allowing proteins and other plasma components from the sinusoids to be taken up by the hepatocytes.

Lola M. Reid. The space contains extracellular matrix proteins HSCs reside in the perisinusoidal space of Disse. Marion Bessin Liver Research Center Albert Einstein College of … This perivascular niche is created by extracellular matrix proteins, sinusoidal endothelial cells, liver parenchymal cells and sympathetic nerve endings and establishes a microenvironment that is suitable to maintain stellate cells and to control their fate. This space separates hepatocytes, which are lined with a low-density basal membrane, from endothelial cells, which form the walls of the hepatic sinusoids. The space of Disse is a smaller continuation of the space of Mall. While the space of Mall enables exchange of arterial and venous blood, along with bile collection and transport out of the liver, the space of Disse provides nutrition to individual liver cells.

肝細胞の 微絨毛 はディッセ腔まで伸展し、類洞からのタンパク質や他の血漿成分の肝細胞への取り込みを可能にする。. While the space of Mall enables exchange of arterial and venous blood, along with bile collection and transport out of the liver, the space of Disse provides nutrition to individual liver cells. It is extremely small and readily passes through capillary walls coming into direct contact with cells throughout the body. Cells with excess cholesterol (small circle with C) have ATP-binding cassette transporter (ABCA-1) on their surface. There is a growing recognition that hepatic cell cultures should mimic the in vivo structure of the liver.

est 1. The space of Disse (or perisinusoidal space) is a location in the liver between a hepatocyte and a sinusoid.It contains the blood plasma. 同義語として 類洞周囲腔 。. Warning of or having dreadful or terrible consequences; calamitous: a dire … Extracellular matrix gradients in the space of disse: Relevance to liver biology. 1,14 … Departments of Molecular Pharmacology and Microbiology and Immunology, New York 10461. The stellate cell is the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. ディッセ腔 ( 英: space of Disse )とは 肝臓 における 肝細胞 と 類洞 の間の領域。.
Space of disse in Liver.
Disse Space.